A Palette of Thought May be Reborn

Hi there everyone.  It has been a while since I’ve posted on this blog.  I have spent a few years posting on a website called “Thoughts.com“, but I am thinking that it may be a good idea for me to start using WordPress so that I can reach a broader audience.  It has been so long that I doubt I have any remaining followers here, but I may attempt to build my listener base back up and go from there.   I hope everyone is doing well and hopefully there will be good things to come.

 

Warm Regards,

Jacob

My Blog Has Moved! :O

Hello everyone!  If you are interested in checking out more of my poetry/writing, my blog has moved to:

http://jakevince.thoughts.com/

 

Feel free to check it out!

 

Thanks everyone! 🙂

 

-Jacob

Guardian

Guardian

Jacob Vinson

Turn your third eye to the sky
Take a deep breath
And fly

Grab the reigns of your soul
And thrust it upwards
Towards the stars
And breathe in deeply

Never again question the past
Never question the future
Take aim to the heavens
And never look back

Ignite the wick that is your hope
And look through a different scope
A kaleidoscope of unique joy
A myriad of shapes and pieces-
Lost fragments of time and memory
All within view

Put together the pieces
One by one
Each is a voyage
On a finely written page

Write the story of your life while dreaming
In this unknown place full of unseen feelings
Each chapter with beautiful prose, gleaming

Close the finished tale
Smile and breathe out a revelation
A new world of your creation
Your last chance at salvation

Awake renewed, my child
Like a newly sowed seed, ready to sprout
Saved from fear and cleansed from doubt
Your desolate world has been turned inside out
You are now at peace
In a garment, woven with soft fleece
Garnished with gold, silver, and jewel
Your soul has met its final renewal

You may rest, my child
No more nightmares of the cruel and wild
Just my voice in your palace of white
Where there is never a bad night
Where happiness is always in sight
You’ll never again be alone or scared
My arms are around you
A perfect life is ours to be shared
I am your guardian
I am prepared

Within Flames

I’m

Staring through…

Alluring, enticing

The embers fight

Through rising light

Brightening the dead of night

 

Hungry, wanting

A catalyst, a source of energy

A reason to live, to grow

To consume and ravage

Anything that gets in its way

 

What a monster you are

What a fiendish entity

As I use you for warmth

You use me to feed you

Any forgotten stems or twigs

Who have seen better days

But never, ever again

 

Not another spring will they bloom,

Blossom and grow towards the sunlight

Now they are yours to keep

Inside your quivering heart

 

Please remember their journey

Don’t forget the dead

For a spot of rain is all it takes

For you to meet your own demise

 

But if you keep this promise

To be humble, modest and meek

I will remember you

 

Keep me warm just one last time

Or try to devour me

It is your choice now

A Cure for Cancer?

Toxin From Coral-reef Bacteria Could Become Next-generation Cancer Drug

Toxin From Coral-reef Bacteria Could Become Next-generation Cancer Drug

ScienceDaily (Nov. 29, 2007) — University of Michigan (U-M) and Scripps Institution of Oceanography at UC San Diego researchers have acquired a new molecular tool that could help them transform a toxin from coral-reef bacteria into a next-generation cancer drug.


A clump of L. majuscula bacteria collected from a reef is shown underwater off Panama. These bacteria create a potent toxin that has proven effective against several human cancers in laboratory tests. (Credit: Image courtesy of Scripps Institute Of Oceanography)

A clump of L. majuscula bacteria collected from a reef is shown underwater off Panama. These bacteria create a potent toxin that has proven effective against several human cancers in laboratory tests. (Credit: Image courtesy of Scripps Institute Of Oceanography)

U-M Life Sciences Institute researchers David Sherman and Janet Smith led a cross-disciplinary team that uncovered new functions for an ancient, well-known family of proteins found in many organisms, from microbes to humans.

The discovery of new roles for the GNAT family of proteins adds weapons to the arsenal of “synthetic biologists” who rearrange the building blocks of natural substances in an effort to make better pharmaceuticals, said Sherman, director of LSI’s Center for Chemical Genomics and the Hans W. Valteich professor of medicinal chemistry at the U-M College of Pharmacy.

“Nature usually gives us sub-optimal drug candidates,” Sherman said. “But we can chop them apart and reassemble them at will to engineer compounds that may have better properties as drugs.”

The Sherman team, along with William Gerwick of Scripps’ Center for Marine Biotechnology and Biomedicine and the Skaggs School of Pharmacy and Pharmaceutical Sciences at UC San Diego, analyze chemical compounds pulled from marine organisms living in coral reef sediments, blue-green algae, sponges and soft corals. They look for substances, such as bacterial toxins, that can kill or disable cancer cells in the laboratory. Currently, more than a dozen such compounds from marine sources are in pre-clinical or clinical trials as cancer therapeutics.

One such substance is curacin A, a leading anti-cancer drug candidate first derived from a Caribbean coral reef cyanobacterium, L. majuscula, in 1994 by Gerwick’s group. In the lab, curacin A is effective against colon, kidney and breast cancer cell lines.

Sherman and his colleagues have been trying to understand how the biochemical machines inside L. majuscula assemble the curacin A molecule. In 2004, the group published a blueprint showing all the proteins that are responsible for making the curacin A molecular chain.

Since then, they’ve focused on determining the functions of the roughly 60 biological catalysts used in the assembly line-like curacin A synthesis process. The team’s latest finding is that the first links in the curacin-A chain include a member of the GNAT family of proteins, a group of enzymes that has long been known to play roles in gene regulation, hormone synthesis and antibiotic resistance.

The big surprise was finding that a GNAT enzyme helps initiate the chain-building process that forms curacin A. “It’s a totally new function for these GNAT enzymes,” Sherman said.

“Decoding these biosynthetic pathways is like trying to understand a series of hieroglyphics,” he said. “And this GNAT discovery is like finding the Rosetta stone. It helps us decipher previously unknown or misunderstood symbols.”

While Sherman’s group carried out the enzymology for the study, Smith’s team captured X-ray crystallography images of the GNAT enzyme’s structure. Smith is director of LSI’s Center for Structural Biology. Gerwick’s team made the original discovery of curacin A and provided the cyanobacterial DNA for this study.

L. majuscula is a cyanobacterium, which are among the oldest organisms on Earth. Roughly 3 billion years ago, cyanobacteria began producing atmospheric oxygen that, much later, allowed more complex life forms to emerge. In the L. majuscula bacterium, the curacin A toxin likely performs a defense function, possibly protecting the microbe from predators.

This research is detailed in the November 9 issue of the journal Science.

Resonate

Resonate

Jacob Vinson

Alone gain tonight

A cold hand touches mine

Sensation follows throughout

And reaches my lonely mind

It says to me in a dreary tone

Forget your worries, forget your pain

Dig into the rhythm, do your walk of fame

Dance through the fire, dancing toward the sky

Dance into a memory, and the vision begins to die

Forget your worries, kill your pain

Dig into the rhythm, do your walk of fame

The deception, the hate

They resonate

I wait the day that I can feel

The touch from a warm hand

Forget your worries, kill your pain

Dig into the rhythm, do your walk of fame

The deception, the hate

They resonate

Love and war,

They both grow and fall

So I dig into the rhythm

And soon I’ll have it all

Help Animals in Need

cute-kittenweeeThe ASPCA was founded in 1866 as the first humane organization in the Western Hemisphere. The Society was formed to alleviate the injustices animals faced then, and we continue to battle cruelty today. Whether it’s saving a pet who has been accidentally poisoned, fighting to pass humane laws, rescuing animals from abuse or sharing resources with shelters across the country, we work toward the day in which no animal will live in pain or fear. Learn more about the ASPCA »
http://www.aspca.org/

Come and join us in the fight to end animal cruelty—become an ASPCA Member today!